General information about the 4F-PHP
The systematic and formal IUPAC name of 4F- PHP is 1-(4-fluorophenyl)-2-(pyrrolidin-1-yl) hexan-1-one. The empirical formula of this chemical is C16H22FNO while the relative molar mass is 263.35 grams. It may also be attributed to the name of 4-fluro-pyrrolidinohexiophenone. Sometimes, by fluorinating a drug compound, the lipophilicity and bioavailability of that drug can be increased. Because of the high electronegative character of fluorine, topographical molecule charge that interfere with the metabolism can be changed, hence providing the compound with a significantly longer half- life. Fluorine is an electronegative atom which has to make the carbonyl pretty less polar, thereby reducing the reactivity of the compound.
4F-PHP is basically a drug compound that belongs to a special class of chemicals which is called substituted cathinones. Cathinone is a chemical compound which is derived from the “Khat”, a plant which is native to the African horn. This class of chemicals feature phenethylamine backbone by the help of a ketone placed at the beta carbon position whereas, carious alkyl moieties are substituted at the position of alpha carbon present adjacent to the amine. The structural arrangement helps increase the lipophilicity to these specific cathinones.
Effects of 4F- PHP
There are many other cathinone compounds with a similar structure as that of 4F- PHP. The similar compounds are known to cause many stimulatory effects upon consumption. Some of cathinone compounds have been reported to act as entactogens and some have been studied to have a potential of inducing euphorbia state. As already mentioned, the class of cathinones comes from a plant called Khat. This plant has been in use by many indigenous people who have reported the compound to cause some desired pleasant stimulatory effect on the person consuming this drug.
The substituted cathinone has a short time of human usage. In the last 15 years, the first compounds being used were mephedrone and methylone. These compounds were present online and thus received worldwide popularity. The reported effects of these drugs were the same as that of the initial psychoactives like amphetamine, MDMA and the cocaine. The unverifiable and subjective reports are present online which suggest that this compound is really strong and helps in inducing stimulation, rush and euphorbia. However, still the research is in phase and nothing can be said about the authenticity of the reported effects of this chemical. There can be less, or more severe effects of 4F- PHP and it is better not to start using this chemical before it is regarded as safe for human consumption by the scientists and researchers.
Prohibiting sale of 4F- PHP
Some restrictive legislation is being passed against 4F- PHP restricting the sale of these compounds. The substituted cathinones are high in demand which is why different other substituted cathinones have emerged just like 4F- PVP, α-PHP, MDPV and α-PVP. By changing the structure, different changes can be induced in toxicity, side effects, action or duration and in the subjective effects. Not only 4F- PHP, there are many other substituted cathinones which are being prohibited. This is the reason why more and different other substituted cathinones are coming in the market. They are emerging and creating hindrance in the research projects too, since the researchers are unable to collect information regarding the profiles of all the substituted cathinones. In order to avoid any sort of legislation, some continual modifications are mind.