What is jwh-018
Buy JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2.
It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products such as “legal cannabis herbal incense blends” which in some countries are sold legally as “incense”, labeled “not for human consumption”.
JWH-018 is one of these compounds, with studies showing an affinity for the cannabinoid (CB1) receptor five times greater than that of THC. Buy jwh-018 online, Cannabinoid receptors are found in mammalian brain and spleen tissue; however, the structural details of the active sites are currently unknown. On December 15, 2008, it reported by the German pharmaceutical company THC Pharm that JWH-018 was found as one of the active components in at least three versions of the herbal blend Spice, which has been sold as an incense in a number of countries around the world since 2002.
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An analysis of samples acquired four weeks after the German prohibition of JWH-018 took place found that the compound had been replaced with JWH-073.
JWH-018 a full agonist of both the CB1 and CB2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB1 and 2.94 ± 2.65 nM at CB2. Thus, JWH-018 has an EC50 of 102 nM for human CB1 receptors, and 133 nM for human CB2 receptors.
JWH-018 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting
potent cannabinoid-like activity.
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Metabolism of JWH-018 was assessed using Wistar rats which had been administered an ethanolic extract containing JWH-018. Urine was collected for 24 hours, followed by extraction of JWH-018 metabolites using
both liquid-liquid extraction and solid-phase extraction.
GC-MS utilized to separated and identify the extracted compounds. JWH-018 and N-dealkylated metabolite were only detected in small amounts, with hydroxylated N-dealkylated metabolites comprising the primary signal. Buy jwh-018 online.
The observed mass shift indicates that it likely that hydroxylation occurs in both the naphthalene and indole portions of the molecule.
Human metabolites were similar although most metabolism took place on the indole ring and pentyl side chain, and the hydroxylated metabolites were extensively conjugated with glucuronide.
At least one case of JWH-018 dependence has been reported by the media. The user consumed JWH-018 daily for eight months. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence.
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JWH-018 has shown to cause profound changes in CB1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids. On October 15, 2011, Anderson County coroner Greg Shore attributed the death of a South Carolina college basketball player to “drug toxicity and organ failure” caused by JWH-018.
An email dated Nov 4, 2011 concerning the case finally released by the city of Anderson S.C. on Dec 16, 2011 under the Freedom of Information Act after multiple requests by media to see the information had been denied.
Compared to THC, which is a partial agonist at CB1 receptors, JWH-018, and many synthetic cannabinoids, are full agonists. THC has shown to inhibit GABA receptor neurotransmission in the brain via several pathways.
JWH-018 may cause intense anxiety, agitation, and, in rare cases (generally with non-regularJWH users). This has assumed to have been the cause of seizures and convulsions by inhibiting GABA neurotransmission more effectively than THC.
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Cannabinoid receptor full agonists may present serious dangers to the user when used to excess. Various physical and psychological adverse effects have reported from JWH-018 use. Buy jwh-018 online one study reported psychotic relapses and anxiety symptoms in well-treated patients with mental illness following JWH-018 inhalation.
Due to concerns about the potential of JWH-018 and other synthetic cannabinoids to cause psychosis in vulnerable individuals. It has recommended that people with risk factors for psychotic illnesses (like a past or family history of psychosis) not use these substances.
JWH-018 usage readily detected in urine using “spice” screening immunoassays from several manufacturers. Focused on both the parent drug and its omega-hydroxy and carboxyl metabolites.
JWH-018 will not detected by older methods employed for detecting THC and other cannabis terpenoids. Determination of the parent drug in serum or its metabolites in urine has accomplished
by GC-MS or LC-MS.
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